CJC-1295 + Ipamorelin

The most-researched GH secretagogue combination. CJC-1295 without DAC (GHRH analog) drives GH pulse amplitude. Ipamorelin (selective GHRP) drives GH pulse frequency without cortisol or prolactin elevation. Synergistic GH axis research stack.

GH / PerformanceGHRH + GHRP StackCJC-1295 w/o DACIpamorelinSynergistic GHInjectable

QUICK FACTS

CJC-1295GHRH analog — drives GH pulse amplitude

IPAMORELINSelective GHRP — drives GH pulse frequency

SYNERGYAmplitude + frequency = maximal GH release

CORTISOLIpamorelin does NOT elevate cortisol — key advantage

SIZES10mg+10mg and 20mg+20mg vial configurations

Overview

The CJC-1295 + Ipamorelin stack is the most widely researched GH secretagogue combination in physician practice. Two complementary mechanisms: CJC-1295 (GHRH analog) increases GH pulse amplitude by amplifying pituitary GH release; Ipamorelin (selective GHRP/GHS) increases GH pulse frequency through ghrelin receptor (GHSR) activation. Amplitude plus frequency produces substantially greater total GH output than either compound alone. Ipamorelin’s selectivity is critical — unlike GHRP-6 or GHRP-2, it does not elevate cortisol or prolactin at research doses, making it the cleanest GHRP for combination use. Available in 10mg+10mg and 20mg+20mg vial configurations.

Research Areas

GH axis researchGHRH + GHRP synergy researchPituitary function researchGrowth hormone secretagogue researchBody composition researchRecovery and anti-aging research

Available Evidence

Physician Practice DataCJC-1295 and Ipamorelin are among the most-used compounds in physician-directed GH research. Extensive physician practice data.

Component ClinicalCJC-1295: human GH and IGF-1 elevation data published. Ipamorelin: human Phase I/II data available with selective GH stimulation profile.

MechanisticGHRH + GHRP dual-axis synergy well-characterized pharmacologically. Amplitude x frequency mechanism documented.

Documented Research Benefits

GH pulse amplitude

CJC-1295 GHRH

GH pulse frequency

Ipamorelin GHRP

No cortisol elevation

Ipamorelin selectivity

IGF-1 elevation

combined

Body composition research

GH/IGF-1 axis

Recovery research

GH/IGF-1

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Safety & Regulatory Status

Both components have physician practice data. Ipamorelin preferred for cortisol-neutral GH axis research. Not FDA-approved as secretagogues. All information educational reference only.