Physician PracticeResearch Use OnlyWADA Prohibited
BPC-157
Body Protection Compound-157 — a 15-amino acid peptide studied for tissue repair, gastrointestinal protection, and soft-tissue recovery in preclinical and limited human research contexts.
RecoveryTissue RepairGI ProtectionInjectableOral
QUICK FACTS
FORMULAC₆₂H₉₈N₁₆O₂₂
MOLECULAR WEIGHT1419.53 g/mol
SEQUENCEGEPPPGKPADDAGLV
MECHANISMPromotes angiogenesis and tissue healing
EVIDENCE STATUSPhysician practice / limited human data
CAS NUMBER137525-51-0
Overview
BPC-157 (Body Protection Compound-157) is a synthetic pentadecapeptide derived from a protein found naturally in gastric juice. It consists of 15 amino acids and has been studied primarily in preclinical models for its effects on tissue repair, wound healing, and gastrointestinal protection.
In research contexts, BPC-157 is thought to act through multiple pathways including the promotion of angiogenesis (new blood vessel formation), upregulation of growth hormone receptors, and modulation of nitric oxide pathways. These mechanisms are proposed to underlie its observed effects on soft-tissue recovery and GI mucosal protection in animal studies.
While preclinical data is extensive — spanning tendon, ligament, muscle, bone, and gut studies — human clinical trial data remains limited. Most physician-supervised use is extrapolated from animal research and practitioner case experience. It is not approved by the FDA for any indication and is classified as a research compound for investigational use only.
Research Areas
Gastrointestinal mucosal protectionTendon and ligament healingWound healing and angiogenesisAnti-inflammatory effectsMuscle tissue repairBone healingNitric oxide pathway modulation
Available Evidence3 categories
HumanA Phase II clinical trial for inflammatory bowel disease showed no significant adverse effects. Limited case reports and physician practice data support GI and soft-tissue applications.
In VitroCell culture studies demonstrate tenocyte stimulation and pro-angiogenic activity supporting proposed mechanisms of VEGF upregulation and GI cytoprotection.
UncertainClaims of systemic whole-body healing and athletic performance enhancement are not supported by published controlled human trials.
Key Studies & Findings4 studies
Preclinical2004
BPC-157 accelerated healing of transected rat Achilles tendon and stimulated tenocyte growth in vitro, supporting tendon-healing effects.
Preclinical2018
Seiwerth S, et al. reviewed BPC-157 cytoprotective and regenerative properties with focus on GI protection and angiogenic mechanisms. Current Pharmaceutical Design. DOI:10.2174/1381612824666180712110447
Preclinical2019
Gwyer D, et al. demonstrated BPC-157’s role in accelerating musculoskeletal soft tissue healing. Cell Tissue Research. DOI:10.1007/s00441-019-03016-8
Review2024
Kang EA, et al. reviewed BPC-157 in inflammatory bowel conditions. Inflammopharmacology. DOI:10.1007/s10787-024-01499-8
Documented Research Benefits8 documented
Accelerated wound healing
preclinical
Tendon and ligament repair
preclinical
GI mucosal protection
human / preclinical
Anti-inflammatory effects
preclinical
Angiogenesis promotion
in vitro / preclinical
Muscle tissue regeneration
preclinical
Nitric oxide modulation
preclinical
NSAID damage counteraction
preclinical
Research Pairings3 common
TB-500 (Thymosin Beta-4)
Most common pairing. BPC-157 handles structural repair, TB-500 targets cell migration and systemic recovery. Often used at 1:1 ratio in acute protocols.
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Safety & Regulatory Status
BPC-157 is not approved by the FDA for any indication and is prohibited under WADA regulations. It is sold strictly for laboratory and research use only, not intended for human consumption, self-administration, or therapeutic use.
Long-term human safety data is limited. No lethal dose has been established in toxicology studies. All information on this page is for educational reference only and does not constitute medical advice.